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CEP-1347
CAS No. 156177-65-0
CEP-1347( KT-7515 | KT 7515 | CEP 1347 )
Catalog No. M12222 CAS No. 156177-65-0
CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCEP-1347
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NoteResearch use only, not for human use.
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Brief DescriptionCEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM.
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DescriptionCEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM; has weak inhibitory activity for Trk A and MLCK; promotes motoneuron survival and simultaneously inhibits the JNK1 signaling cascade; inhibits recombinant MLK1/2/3 with IC50 of 23-51 nM; blocks cell death (overexpression of MLK3) in CHO cells; elicits neuroprotective and anti-inflammatory responses in models of neurodegenerative diseases.Parkinson Disease Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsKT-7515 | KT 7515 | CEP 1347
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PathwayMAPK/ERK Signaling
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TargetMLK
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RecptorMLK
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Research AreaNeurological Disease
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IndicationParkinson Disease
Chemical Information
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CAS Number156177-65-0
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Formula Weight615.76
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Molecular FormulaC33H33N3O5S2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C([C@]1(O)[C@@](O2)(C)N3C4=CC=C(CSCC)C=C4C5=C3C6=C(C7=CC(CSCC)=CC=C7N6[C@@]2([H])C1)C8=C5CNC8=O)OC
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Chemical Namemethyl (5R,7R,8S)-2,11-bis((ethylthio)methyl)-7-hydroxy-15-oxo-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-7-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kaneko M, et al. J Med Chem. 1997 Jun 6;40(12):1863-9.
2. Maroney AC, et al. J Neurosci. 1998 Jan 1;18(1):104-11.
3. Maroney AC, et al. J Biol Chem. 2001 Jul 6;276(27):25302-8.
4. Eggert D, et al. J Immunol. 2010 Jan 15;184(2):746-56.
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