CDP-840

CAS No. 162542-90-7

CDP-840 ( CDP840;L-765527 )

Catalog No. M12403 CAS No. 162542-90-7

CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE 4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CDP-840
  • Note
    Research use only, not for human use.
  • Brief Description
    CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE 4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast.
  • Description
    CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE 4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast; shows no effect for PDE-1, 2, 3, 5, and 7 (IC50>100 uM), exhibits no significant selectivity in inhibiting human recombinant isoenzymes PDE-4A, B, C or D and is equally active against the isoenzymes lacking UCR1 (PDE-4B2 and PDE-4D2); causes a dose-dependent reduction of IL-5-induced pleural eosinophilia in rats (ED50=0.03 mg/kg); prevents antigen-induced eosinophilia and bronchoconstriction; orally active.Asthma Phase 2 Discontinued
  • Synonyms
    CDP840;L-765527
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Inflammation/Immunology
  • Indication
    Asthma

Chemical Information

  • CAS Number
    162542-90-7
  • Formula Weight
    373.50
  • Molecular Formula
    C25H27NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COC1=CC=C([C@@H](C2=CC=CC=C2)CC3=CC=NC=C3)C=C1OC4CCCC4.[H]Cl
  • Chemical Name
    4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hughes B, et al. Br J Pharmacol. 1996 Jul;118(5):1183-91.
2. Holbrook M, et al. Br J Pharmacol. 1996 Jul;118(5):1192-200.
3. Perry MJ, et al. Cell Biochem Biophys. 1998;29(1-2):113-32.
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