CDP-840

Research use only, not for human use.

CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE 4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast.

CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE 4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast; shows no effect for PDE-1, 2, 3, 5, and 7 (IC50>100 uM), exhibits no significant selectivity in inhibiting human recombinant isoenzymes PDE-4A, B, C or D and is equally active against the isoenzymes lacking UCR1 (PDE-4B2 and PDE-4D2); causes a dose-dependent reduction of IL-5-induced pleural eosinophilia in rats (ED50=0.03 mg/kg); prevents antigen-induced eosinophilia and bronchoconstriction; orally active.Asthma Phase 2 Discontinued.

——

——

CDP840 | L-765527

Angiogenesis

PDE

PDE

Inflammation/Immunology

Asthma

162542-90-7

373.496

C25H27NO2

>98% (HPLC)

——

COC1=CC=C([C@@H](C2=CC=CC=C2)CC3=CC=NC=C3)C=C1OC4CCCC4.[H]Cl

4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine

(-20℃)

With Ice Pack

≥ 2 years