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Home - Products - PI3K/Akt/mTOR signaling - GSK-3 - CDK8-IN-12

CDK8-IN-12

CAS No. 2613307-67-6

CDK8-IN-12( —— )

Catalog No. M36414 CAS No. 2613307-67-6

CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CDK8-IN-12
  • Note
    Research use only, not for human use.
  • Brief Description
    CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent.
  • Description
    CDK8-IN-12 is an orally active, potent CDK8 inhibitor with a Ki of 14 nM. CDK8-IN-12 has off-target kinase inhibition on GSK-3α, GSK-3β, PCK-θ with Kis of 13 nM, 4 nM, 109 nM, respectively. CDK8-IN-12 shows potent anti-proliferative effects selectively on MV4-11 cell. CDK8-IN-12 is an anti-cancer agent.
  • In Vitro
    Western Blot Analysis Cell Line:MV4-11 cells Concentration:0.36, 0.72 μM Incubation Time:2 hours Result:Significantly reduced the phosphorylation of serine 727 on STAT1 at concentrations of their respective 1× GI50 values, but barely affected the level of total STAT1.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    GSK-3 | CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2613307-67-6
  • Formula Weight
    381.86
  • Molecular Formula
    C21H20ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C2(CCN(CC2)C=3C(=CN=CC3Cl)C4=CC=5C(O4)=CC=CC5)CCN1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mingfeng Yu, et al. Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation. Eur J Med Chem. 2021 Mar 15;214:113248.?
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