CDDO-dhTFEA

Research use only, not for human use.

CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.

CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.

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RTA dh404

Apoptosis

NF-κB

NF-κB|Nrf2

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1191265-33-4

574.72

C33H45F3N2O3

>98% (HPLC)

DMSO:100 mg/mL (174.00 mM; Need ultrasonic)

C[C@@]12CC[C@@H]3[C@@]([C@H]1CC(=O)[C@H]4[C@]2(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)NCC(F)(F)F)C)(C=C(C(=O)C3(C)C)C#N)C

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(-20℃)

With Ice Pack

≥ 2 years