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CDDO-dhTFEA
CAS No. 1191265-33-4
CDDO-dhTFEA( RTA dh404 )
Catalog No. M23361 CAS No. 1191265-33-4
CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 84 | In Stock |
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| 5MG | 140 | In Stock |
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| 10MG | 241 | In Stock |
|
| 25MG | 484 | In Stock |
|
| 50MG | 699 | In Stock |
|
| 100MG | 981 | In Stock |
|
| 500MG | 1953 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCDDO-dhTFEA
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NoteResearch use only, not for human use.
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Brief DescriptionCDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.?
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DescriptionCDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.?It restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.
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In Vitro——
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In Vivo——
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SynonymsRTA dh404
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB|Nrf2
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Research Area——
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Indication——
Chemical Information
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CAS Number1191265-33-4
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Formula Weight574.72
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Molecular FormulaC33H45F3N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (174.00 mM; Need ultrasonic)
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SMILESC[C@@]12CC[C@@H]3[C@@]([C@H]1CC(=O)[C@H]4[C@]2(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)NCC(F)(F)F)C)(C=C(C(=O)C3(C)C)C#N)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biol. 2013 Oct 31;1:527-31.
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CDDO-dhTFEA
CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.?
