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CDDO-EA

CAS No. 932730-51-3

CDDO-EA( CDDO ethyl amide | TP319 | RTA 405 )

Catalog No. M26099 CAS No. 932730-51-3

CDDO-EA is an activator of the Nrf2/antioxidant response element.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CDDO-EA
  • Note
    Research use only, not for human use.
  • Brief Description
    CDDO-EA is an activator of the Nrf2/antioxidant response element.
  • Description
    CDDO-EA is an activator of the Nrf2/antioxidant response element.(In Vitro):In a cell culture model of ALS, CDDO-EA potently activates Nrf2/ARE . CDDO-EA induces apoptosis in A549 lung cancer cells and induces heme oxygenase-1. CDDO-EA is 7-fold more potent than CDDO as a suppressor of the ability of IFN-γ to induce iNOS in RAW264.7 macrophage-like cells.(In Vivo):CDDO-EA-treated G93A mice live significantly longer than the control. CDDO-EA increases the life-span from 124.05 days to 144.72 days (16.6%). In CDDO-EA-treated G93A mice, the age of death is 141.4 days and the duration from the age of onset to the age of death is 57.6 days. The age of death from the onset is prolonged by 17.5 days (43%) .
  • In Vitro
    CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. CDDO-EA is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS.
  • In Vivo
    The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%).
  • Synonyms
    CDDO ethyl amide | TP319 | RTA 405
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    Keap1-Nrf2
  • Recptor
    E3 Ligase Ligand-Linker Conjugate
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    932730-51-3
  • Formula Weight
    518.73
  • Molecular Formula
    C33H46N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 16.67 mg/mL (32.14 mM)
  • SMILES
    C(NCC)(=O)[C@]12[C@]([C@@]3([C@@](C)(CC1)[C@@]4(C)C(=CC3=O)[C@]5(C)[C@@](CC4)(C(C)(C)C(=O)C(C#N)=C5)[H])[H])(CC(C)(C)CC2)[H]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Guangrong Zheng, et al. Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof. WO2017184995A1.
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