CD73-IN-4

Research use only, not for human use.

CD73-IN-4 is a potent and selective methylenephosphonic acid?CD73?inhibitor.

CD73-IN-4 is a potent and selective methylenephosphonic acid?CD73?inhibitor.

CD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC50 = 0.86 nM) and soluble mouse CD73 (mCD73; IC50 = 3.0 nM), CHO cells overexpressing hCD73 (IC50 = 2.6 nM) or mCD73 (IC50 = 13 nM), and the human ovary cancer cell line SKOV-3 (IC50 = 0.55 nM). It exhibits excellent selectivity (IC50 > 10?000 nM) against CD39, A2aR, and NTPDase2, 3, and 8.

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Others

Other Targets

CD73

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2216764-29-1

463.81

C16H23ClN5O7P

>98% (HPLC)

DMSO:125 mg/mL?(265.19 mM;?Need ultrasonic)

O[C@H]1[C@H](N2N=CC3=C(NC4CCCC4)N=C(Cl)N=C32)O[C@H](COCP(O)(O)=O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years