CCT018159( —— )

Catalog No. M21862 CAS No. 171009-07-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CCT018159
Note

Research use only, not for human use.
Brief Description

The heat shock protein 90 (Hsp90) is a molecular chaperone that activates and maintains the biological functioning of several client proteins, many of which are associated with oncogenic signaling pathways.
Description

The heat shock protein 90 (Hsp90) is a molecular chaperone that activates and maintains the biological functioning of several client proteins, many of which are associated with oncogenic signaling pathways. Its activity is driven by ATP and regulated by co-chaperones such as Hsp72. CCT018159 is a 3,4-diaryl pyrazoloresorcinol compound that inhibits the ATPase activity of Hsp90 with IC50 values of 3.2 and 6.6 μM for human Hsp90β and yeast Hsp90, respectively.At concentrations up to 100 μM, CCT018159 does not inhibit human Hsp72 ATPase or topoisomerase II, yet at 50 μM CCT018159 inhibits 13 out of a panel of 20 commonly studied kinases.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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CAS Number

171009-07-7
Formula Weight

352.4
Molecular Formula

C20H20N2O4
Purity

>98% (HPLC)
Solubility

DMSO: 30 mg/ml
SMILES

CCc1cc(c(O)cc1O)c1n[nH]c(C)c1c1ccc2OCCOc2c1
Chemical Name

4-[4-(2,3-dihydo-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol