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CCI-006

CAS No. 292053-42-0

CCI-006( —— )

Catalog No. M22449 CAS No. 292053-42-0

CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 129 In Stock
5MG 222 In Stock
10MG 349 In Stock
25MG 583 In Stock
50MG 833 In Stock
100MG 1134 In Stock
500MG 2268 In Stock
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Biological Information

  • Product Name
    CCI-006
  • Note
    Research use only, not for human use.
  • Brief Description
    CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
  • Description
    CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Mitochondria
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    292053-42-0
  • Formula Weight
    332.33
  • Molecular Formula
    C15H12N2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:83.33 mg/mL (250.74 mM)
  • SMILES
    COC(=O)C(\C#N)=C\c1ccc(o1)-c1ccc(cc1)S(N)(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.
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