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CCI 007
CAS No. 939228-52-1
CCI 007( —— )
Catalog No. M24990 CAS No. 939228-52-1
CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 81 | In Stock |
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| 5MG | 125 | In Stock |
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| 10MG | 200 | In Stock |
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| 25MG | 394 | In Stock |
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| 50MG | 584 | In Stock |
|
| 100MG | 833 | In Stock |
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| 500MG | 1683 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCCI 007
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NoteResearch use only, not for human use.
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Brief DescriptionCCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
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DescriptionCCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
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In VitroCCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia.Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal. CCI-007 alters the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2.Resistance to CCI-007 can occur by upregulation of MLL target gene expression. :Cell Viability Assay Cell Line:PER-485, MOLM-13, MV4;11 cells.Concentration:5 μM.Incubation Time:24 h.Result:Induced apoptosis.
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorMLL-r
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Research Area——
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Indication——
Chemical Information
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CAS Number939228-52-1
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Formula Weight336.36
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Molecular FormulaC15H16N2O5S
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESO=C(OCC)COC(C=CC(C=C1SC(N)=NC1=O)=C2)=C2OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Somers K , Chudakova D A , Middlemiss S , et al. CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements[J]. Oncotarget, 2016, 7(29):46067-46087.
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