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CCG-63802

CAS No. 620112-78-9

CCG-63802 ( —— )

Catalog No. M26640 CAS No. 620112-78-9

CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CCG-63802
  • Note
    Research use only, not for human use.
  • Brief Description
    CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins.
  • Description
    CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins. CCG-63802 inhibits the interaction between RGS4 and Galpha with an IC50 value of 1.4 μM.(In Vitro):CCG-63802 showed selectivity among RGS proteins with a potency order of RGS 4 > 19 = 16 > 8 ? 7. CCG-63802 inhibited the GTPase accelerating protein activity of RGS4.(In Vivo):The attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodeling was partially abrogated by administration of RGS4 inhibitor CCG-63802(0.5 mg/kg). The downregulation of RGS4 by CCG-63802 also significantly increased inflammatory cell accumulation and AHR, and increased levels of IL-4, IL-13, eotaxin, IFN-γ, and IL-17A in BALF, and total and OV-specific IgE in serum. The inhibitory effects of PGZ on the activations of ERK and Akt/mTOR signaling, and MMPs were apparently reversed by CCG-63802 administration.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Microtubule/Tubulin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    620112-78-9
  • Formula Weight
    450.5
  • Molecular Formula
    C26H18N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1cccc(Oc2nc3c(C)cccn3c(=O)c2\C=C(/C#N)c2nc3ccccc3s2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gardner ER, et al. Antiangiogenic and antitumor activity of LP-261, a novel oral tubulin binding agent, alone and in combination with bevacizumab. Invest New Drugs. 2012 Feb;30(1):90-7.
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