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CCF642
CAS No. 346640-08-2
CCF642 ( CCF-642; CCF 642; CCF642 )
Catalog No. M17489 CAS No. 346640-08-2
CCF642 is a novel PDI-inhibiting compound with antimyeloma activity.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 39 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 95 | In Stock |
|
| 25MG | 186 | In Stock |
|
| 50MG | 332 | In Stock |
|
| 100MG | 478 | In Stock |
|
| 500MG | 1062 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCCF642
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NoteResearch use only, not for human use.
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Brief DescriptionCCF642 is a novel PDI-inhibiting compound with antimyeloma activity.
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DescriptionCCF-642 is a protein disulfide isomerase (PDI) inhibitor. CCF642 exhibited a submicromolar IC50 in 10 of 10 multiple myeloma cell lines. In vitro, CCF642 inhibited PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib.
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SynonymsCCF-642; CCF 642; CCF642
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PathwayAngiogenesis
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TargetEGFR
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Recptorprotein disulfide isomerases
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number346640-08-2
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Formula Weight378.45
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Molecular FormulaC15H10N2O4S3
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Purity98%
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SolubilityDMSO : ≥ 30 mg/mL; 79.27 mM
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SMILESS1C(=S)N(C(=O)/C/1=C\c1ccc(s1)[N+](=O)[O-])c1ccc(cc1)OC
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Chemical Name3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Vatolin S et al. Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma. Cancer Res. 2016 Jun 1;76(11):3340-50.
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