CCF642 ( CCF-642; CCF 642; CCF642 )

Catalog No. M17489 CAS No. 346640-08-2

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Product Name

CCF642
Note

Research use only, not for human use.
Brief Description

CCF642 is a novel PDI-inhibiting compound with antimyeloma activity.
Description

CCF-642 is a protein disulfide isomerase (PDI) inhibitor. CCF642 exhibited a submicromolar IC50 in 10 of 10 multiple myeloma cell lines. In vitro, CCF642 inhibited PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib.
Synonyms

CCF-642; CCF 642; CCF642
Pathway

Angiogenesis
Target

EGFR
Recptor

protein disulfide isomerases
Research Area

Cancer
Indication

——

CAS Number

346640-08-2
Formula Weight

378.45
Molecular Formula

C15H10N2O4S3
Purity

98%
Solubility

DMSO : ≥ 30 mg/mL; 79.27 mM
SMILES

S1C(=S)N(C(=O)/C/1=C\c1ccc(s1)[N+](=O)[O-])c1ccc(cc1)OC
Chemical Name

3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone

1.Vatolin S et al. Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma. Cancer Res. 2016 Jun 1;76(11):3340-50.

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