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CC-99677
CAS No. 1887069-10-4
CC-99677( —— )
Catalog No. M35108 CAS No. 1887069-10-4
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 187 | Get Quote |
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| 5MG | 250 | Get Quote |
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| 10MG | 432 | Get Quote |
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| 25MG | 730 | Get Quote |
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| 50MG | 984 | Get Quote |
|
| 100MG | 1341 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCC-99677
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NoteResearch use only, not for human use.
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Brief DescriptionCC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.
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DescriptionGamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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RecptorMAPK | HSP
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Research Area——
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Indication——
Chemical Information
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CAS Number1887069-10-4
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Formula Weight469.94
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Molecular FormulaC22H20ClN5O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 37.5 mg/mL (79.80 mM; Ultrasonic (<60°C)
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SMILESCCOCc1cnc(Cl)nc1Oc1ccc2c3c4NC[C@@H](C)NC(=O)c4sc3ccc2n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. WO2020236636
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