CAY10404

Research use only, not for human use.

CAY10404 is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells, with analgesic, anti-inflammatory and anti-cancer activities.

CAY10404 is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells, with analgesic, anti-inflammatory and anti-cancer activities.Treatment with CAY10404 in the range of 10-100 microM caused dose-dependent growth inhibition, with an average 50% inhibitory concentration (IC(50)) of 60-100 micromol/L, depending on the cell line.?Western blot analysis of CAY10404-treated cells showed cleavage of poly (ADP-ribose) polymerase (PARP) and procaspase-3, signifying caspase activity and apoptotic cell death.?CAY10404 treatment inhibited the phosphorylation of Akt, glycogen synthase kinase-3beta and extracellular signal-regulated kinases 1/2 in H460 and H358 cells.

3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T

Chromatin/Epigenetic

COX

COX-1;COX-2;Akt

——

——

340267-36-9

367.34

C17H12F3NO3S

>98% (HPLC)

——

CS(=O)(=O)c1ccc(cc1)-c1noc(c1-c1ccccc1)C(F)(F)F

——

(-20℃)

With Ice Pack

≥ 2 years