CAT639

Research use only, not for human use.

CAT639 is an improved analog of ATV399 that exhibits improved β-cell viability and insulin secretion in the rat insulin-producing INS1E cells and primary rat dispersed islet cells.

CAT639 is an improved analog of ATV399 that exhibits improved β-cell viability and insulin secretion in the rat insulin-producing INS1E cells and primary rat dispersed islet cells, inhibits dimerization of iNOS; reduces the production of nitric oxide (NO) by allosterically inhibiting dimerization of the inducible nitric oxide synthase (iNOS) without affecting its mRNA levels; robustly inhibitscaspase-9 activity at sub-micromolar levels (IC50=0.48 uM), also exhibits potent inhibition of CYP3A4; protects primary rat islet survival and function impaired by cytokines.

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CAT 639 | CAT-639

Immunology/Inflammation

NOS

NOS

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479.551

C25H25N3O5S

>98% (HPLC)

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O=C(C1=CC=C(OCO2)C2=C1)NC3=CC=C(S(=O)(N4C(C5=CC=C(C)N=C5)CCCC4)=O)C=C3

N-(4-((2-(6-methylpyridin-3-yl)piperidin-1-yl)sulfonyl)phenyl)benzo[d][1,3]dioxole-5-carboxamide

(-20℃)

With Ice Pack

≥ 2 years