CARM1-IN-7g ( Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor )

Catalog No. M10096 CAS No. 1020399-49-8

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Product Name

CARM1-IN-7g
Note

Research use only, not for human use.
Brief Description

CARM1-IN-7g is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM.
Description

CARM1-IN-7g is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM, exhibits lower or no activity against a panel of different PRMTs or HKMTs (>80-fold over PRMT1 and SET7); inhibits CARM1-mediated methylation of different substrates (PABP1, CA150, SmB, and H3) up to single-digit micromolar level, significantly and dose-dependently reduces the prostate-specific antigen (PSA) promoter activity in human prostate cancer LNCaP cells, does not affect cell viability.
Synonyms

Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

Cancer
Indication

——

CAS Number

1020399-49-8
Formula Weight

555.26
Molecular Formula

C26H21Br2NO3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 35 mg/mL
SMILES

O=C1/C(CN(CC2=CC=CC=C2)C/C1=C/C3=CC=C(O)C(Br)=C3)=C\C4=CC=C(O)C(Br)=C4
Chemical Name

4-Piperidinone, 3,5-bis[(3-bromo-4-hydroxyphenyl)methylene]-1-(phenylmethyl)-

1. Cheng D, et al. J Med Chem. 2011 Jul 14;54(13):4928-32.

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