C188-9 ( C188-9; C 188-9; C-188-9 )

Catalog No. M18547 CAS No. 432001-19-9

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Product Name

C188-9
Note

Research use only, not for human use.
Brief Description

C188-9 is a Stat3 inhibitor with an IC50 of 4-7 μM.
Description

C188-9 is a STAT3 inhibitor. HDM-induced airway inflammation, remodeling, and Th2/Th17-type cell accumulation involve STAT3 activation that can be prevented by C188-9 treatment. STAT3 inhibition with C188-9 resulted in attenuated skin fibrosis, myofibroblast accumulation, pro-fibrotic gene expression and collagen deposition in both mouse models of skin fibrosis. C188-9 decreased in vitro dermal fibroblast production of fibrotic genes induced by IL-6 trans-signalling and TGF-β. Finally, TGF-β induced phosphotyrosylation of STAT3 in a SMAD3-dependent manner.
Synonyms

C188-9; C 188-9; C-188-9
Pathway

Others
Target

Other Targets
Recptor

STAT3
Research Area

Cancer
Indication

——

CAS Number

432001-19-9
Formula Weight

471.52
Molecular Formula

C27H21NO5S
Purity

98%
Solubility

DMSO : ≥ 62 mg/mL; 131.49 mM
SMILES

O=S(=O)(Nc4cc(c1c2ccccc2ccc1O)c(O)c3ccccc34)c5ccc(OC)cc5
Chemical Name

N-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide

1.Redell MS, et al. Blood. 2011 May 26;117(21):5701-9.

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