C-DIM12

Research use only, not for human use.

C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA.

C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons.

C-DIM12; C-DIM 12; C-DIM-12

Others

Other Targets

Nurr1 activator

Neurological Disease

——

178946-89-9

356.85

C23H17ClN2

98%

DMSO : ≥ 100 mg/mL 280.23 mM; H2O : < 0.1 mg/mL

Clc1ccc(C(c2c[nH]c3c2cccc3)c2c[nH]c3c2cccc3)cc1

1,1-bis(3-indolyl)-1-(p-chlorophenyl)methane

(-20℃)

With Ice Pack

≥ 2 years