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Butoconazole
CAS No. 64872-76-0
Butoconazole( 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole )
Catalog No. M21968 CAS No. 64872-76-0
Butoconazole is an imidazole antifungal agentButoconazole is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 73 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameButoconazole
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NoteResearch use only, not for human use.
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Brief DescriptionButoconazole is an imidazole antifungal agentButoconazole is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.
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DescriptionButoconazole is an imidazole antifungal agentButoconazole is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.Butoconazole 1-BSR is an effective and safe alternative to longer-term therapy with miconazole nitrate (seven days) for vulvovaginal candidiasis.
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In VitroImidazoles generally inhibit the conversion of lanosterol to ergosterol, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell.
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In Vivo——
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Synonyms1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole
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PathwayMicrobiology/Virology
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TargetAntifungal
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RecptorAntifungal
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Research Area——
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Indication——
Chemical Information
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CAS Number64872-76-0
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Formula Weight411.76
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Molecular FormulaC19H17Cl3N2S
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Purity>98% (HPLC)
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SolubilityDMSO:77 mg/ml(187 mM)
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SMILESClc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Walker K A M , Braemer A C , Hitt S , et al. 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent[J]. Journal of Medicinal Chemistry, 1978, 21(8):840-843.2. Brown D , Henzl M R , Kaufman R H . Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group[J]. Journal of Reproductive Medicine, 1999, 44(11):933-938.
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