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Butein

CAS No. 487-52-5

Butein( AC1NQY7L | AC1N-QY7L | AC1N QY7L | CCG-208298 )

Catalog No. M17521 CAS No. 487-52-5

Butein, a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Butein
  • Note
    Research use only, not for human use.
  • Brief Description
    Butein, a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.
  • Description
    Butein is found in Rhuteic verniciflua and Butea monosperma. It induces cell cycle arrest and apoptosis in lung cancer cells, inhibits vessel spouting from aortic rings, and prevents hepatic stellate cell activation.
  • In Vitro
    Cell Viability Assay Cell Line:HeLa cells Concentration:10, 20, and 40 μM Incubation Time:24, 48, and 72 hours Result:Inhibited cell growth in a dose- and time-dependent manner.Western Blot Analysis Cell Line:HeLa cells Concentration:20 μM Incubation Time:24 hours Result:Decreased phosphorylation of AKT, ERK and p38 co-treatment with Cisplatin (20 μM).
  • In Vivo
    Animal Model:Nude mice (12 female 6- or 7-week old) with subcutaneous tumor xenografts Dosage:2 mg/kg Administration:Intraperitoneally; every 2 days; for 3 weeks Result:Enhanced the antitumor effects of Cisplatin in vivo.
  • Synonyms
    AC1NQY7L | AC1N-QY7L | AC1N QY7L | CCG-208298
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    EGFR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    487-52-5
  • Formula Weight
    272.25
  • Molecular Formula
    C15H12O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 35 mg/mL128.56 mM
  • SMILES
    c1cc(c(cc1/C=C/C(=O)c1c(cc(cc1)O)O)O)O
  • Chemical Name
    (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yang EB, et al. Biochem Biophys Res Commun, 1998, 17, 245(2), 435-438.
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