Butein( AC1NQY7L | AC1N-QY7L | AC1N QY7L | CCG-208298 )

Catalog No. M17521 CAS No. 487-52-5

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Datasheet

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Product Name

Butein
Note

Research use only, not for human use.
Brief Description

Butein, a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.
Description

Butein is found in Rhuteic verniciflua and Butea monosperma. It induces cell cycle arrest and apoptosis in lung cancer cells, inhibits vessel spouting from aortic rings, and prevents hepatic stellate cell activation.
In Vitro

Cell Viability Assay Cell Line:HeLa cells Concentration:10, 20, and 40 μM Incubation Time:24, 48, and 72 hours Result:Inhibited cell growth in a dose- and time-dependent manner.Western Blot Analysis Cell Line:HeLa cells Concentration:20 μM Incubation Time:24 hours Result:Decreased phosphorylation of AKT, ERK and p38 co-treatment with Cisplatin (20 μM).
In Vivo

Animal Model:Nude mice (12 female 6- or 7-week old) with subcutaneous tumor xenografts Dosage:2 mg/kg Administration:Intraperitoneally; every 2 days; for 3 weeks Result:Enhanced the antitumor effects of Cisplatin in vivo.
Synonyms

AC1NQY7L | AC1N-QY7L | AC1N QY7L | CCG-208298
Pathway

Others
Target

Other Targets
Recptor

EGFR
Research Area

Cancer
Indication

——

CAS Number

487-52-5
Formula Weight

272.25
Molecular Formula

C15H12O5
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 35 mg/mL128.56 mM
SMILES

c1cc(c(cc1/C=C/C(=O)c1c(cc(cc1)O)O)O)O
Chemical Name

(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one

1. Yang EB, et al. Biochem Biophys Res Commun, 1998, 17, 245(2), 435-438.

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