Butein

Research use only, not for human use.

Butein, a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.

Butein is found in Rhuteic verniciflua and Butea monosperma. It induces cell cycle arrest and apoptosis in lung cancer cells, inhibits vessel spouting from aortic rings, and prevents hepatic stellate cell activation.

Cell Viability Assay Cell Line:HeLa cells Concentration:10, 20, and 40 μM Incubation Time:24, 48, and 72 hours Result:Inhibited cell growth in a dose- and time-dependent manner.Western Blot Analysis Cell Line:HeLa cells Concentration:20 μM Incubation Time:24 hours Result:Decreased phosphorylation of AKT, ERK and p38 co-treatment with Cisplatin (20 μM).

Animal Model:Nude mice (12 female 6- or 7-week old) with subcutaneous tumor xenografts Dosage:2 mg/kg Administration:Intraperitoneally; every 2 days; for 3 weeks Result:Enhanced the antitumor effects of Cisplatin in vivo.

AC1NQY7L | AC1N-QY7L | AC1N QY7L | CCG-208298

Others

Other Targets

EGFR

Cancer

——

487-52-5

272.25

C15H12O5

>98% (HPLC)

DMSO : ≥ 35 mg/mL128.56 mM

c1cc(c(cc1/C=C/C(=O)c1c(cc(cc1)O)O)O)O

(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one

(-20℃)

With Ice Pack

≥ 2 years