Bromosporine ( Bromosporine )

Catalog No. M18093 CAS No. 1619994-69-2

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Bromosporine
Note

Research use only, not for human use.
Brief Description

Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.
Description

Bromosporine is a broad spectrum inhibitor for bromodomains and as such will be very useful in elucidating further biological roles of reader domains as well as a tool for the validation of functional assays. Proteins that contain BRDs have been implicated in the development of a large variety of diseases, including various cancers, inflammatory diseases and neurological diseases and the therapeutic potential of bromodomain inhibition has been shown in several of these diseases, such as HIV, cancer and inflammation.
Synonyms

Bromosporine
Pathway

Others
Target

Other Targets
Recptor

BRD
Research Area

Others-Field
Indication

——

CAS Number

1619994-69-2
Formula Weight

404.45
Molecular Formula

C17H20N6O4S
Purity

98%
Solubility

DMSO : ≥ 51.7 mg/mL; 127.83 mM
SMILES

CCOC(=O)Nc1cc(nn2c(C)nnc12)c1cc(NS(=O)(=O)C)c(C)cc1
Chemical Name

ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate

1.15th HELLENIC SYMPOSIUM OF MEDICINAL CHEMISTRY.

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