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Bragsin2

CAS No. 342795-08-8

Bragsin2 ( 6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one; Bragsin 2 )

Catalog No. M26634 CAS No. 342795-08-8

Bragsin2 is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Bragsin2
  • Note
    Research use only, not for human use.
  • Brief Description
    Bragsin2 is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2.
  • Description
    Bragsin2 is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin2 binds at the interface between the pleckstrin homology domain of BRAG2 and the lipid bilayer, leading BRAG2 unable to activate lipidated Arf GTPase.(In Vitro):Administration of 50?μM Bragsin2 inhibits Arf GTPase activation in HeLa cells. Administration of 50?μM Bragsin2 inhibits the growth of breast cancer stem cells including SUM149 and S68, but has no effect on SUM159, which lacks adhesion molecules such as integrin and cadherin.
  • Synonyms
    6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one; Bragsin 2
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Antifungal
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    342795-08-8
  • Formula Weight
    289.2
  • Molecular Formula
    C11H6F3NO5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1ccc2oc(cc(=O)c2c1[N+]([O-])=O)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cimmino A, et al. Phenazine-1-Carboxylic Acid (PCA), Produced for the First Time as an Antifungal Metabolite by Truncatella angustata, a Causal Agent of Grapevine Trunk Diseases (GTDs) in Iran. J Agric Food Chem. 2021 Oct 20;69(41):12143-12147.
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