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Bragsin2
CAS No. 342795-08-8
Bragsin2( 6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one | Bragsin 2 )
Catalog No. M26634 CAS No. 342795-08-8
Bragsin2 is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | Get Quote |
|
| 10MG | 80 | Get Quote |
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| 25MG | 160 | Get Quote |
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| 50MG | 260 | Get Quote |
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| 100MG | 417 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBragsin2
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NoteResearch use only, not for human use.
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Brief DescriptionBragsin2 is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2.
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DescriptionBragsin2 is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin2 binds at the interface between the pleckstrin homology domain of BRAG2 and the lipid bilayer, leading BRAG2 unable to activate lipidated Arf GTPase.(In Vitro):Administration of 50?μM Bragsin2 inhibits Arf GTPase activation in HeLa cells. Administration of 50?μM Bragsin2 inhibits the growth of breast cancer stem cells including SUM149 and S68, but has no effect on SUM159, which lacks adhesion molecules such as integrin and cadherin.
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In VitroBragsin2 (50?μM) inhibits Arf GTPase activation in HeLa cells.Bragsin2 (50?μM) inhibits the growth of SUM149 and S68, with no effect on SUM159, which lacks adhesion molecules such as integrins and cadherins.
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In Vivo——
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Synonyms6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one | Bragsin 2
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PathwayOthers
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TargetOther Targets
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RecptorAntifungal
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Research Area——
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Indication——
Chemical Information
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CAS Number342795-08-8
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Formula Weight289.166
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Molecular FormulaC11H6F3NO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (345.83 mM)
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SMILESCOc1ccc2oc(cc(=O)c2c1[N+]([O-])=O)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cimmino A, et al. Phenazine-1-Carboxylic Acid (PCA), Produced for the First Time as an Antifungal Metabolite by Truncatella angustata, a Causal Agent of Grapevine Trunk Diseases (GTDs) in Iran. J Agric Food Chem. 2021 Oct 20;69(41):12143-12147.
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