Bractoppin
CAS No. 2290527-07-8
Bractoppin ( —— )
Catalog No. M24041 CAS No. 2290527-07-8
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 70 | In Stock |
|
5MG | 113 | In Stock |
|
10MG | 186 | In Stock |
|
25MG | 403 | In Stock |
|
50MG | 592 | In Stock |
|
100MG | 844 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBractoppin
-
NoteResearch use only, not for human use.
-
Brief DescriptionBractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro.
-
DescriptionBractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorOthers
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2290527-07-8
-
Formula Weight414.5
-
Molecular FormulaC25H23FN4O
-
Purity>98% (HPLC)
-
SolubilityDMSO:10 mM
-
SMILESO=C(N1CCN(CC2=CC=CC=C2F)CC1)C3=CC=C4NC(C5=CC=CC=C5)=NC4=C3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Periasamy J , Kurdekar V , Jasti S , et al. Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling[J]. Cell Chemical Biology, 2018:S245194561830076X.
molnova catalog
related products
-
resorufin galactopyr...
resorufin galactopyranoside is a chemical compound.
-
Notoptol
Notoptol is a natural product of Notopterygium, Apiaceae. Notoptol can be used as a reference standard.
-
Phenmedipham
Phenmedipham is a herbicide commonly used in the growth of sugar beets and strawberries.