Bisacodyl

CAS No. 603-50-9

Bisacodyl( Bisacodyl, Durolax, Dulcolax, Fenilaxan, Neolax, Ulcolax )

Catalog No. M15257 CAS No. 603-50-9

Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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500MG 38 In Stock
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Biological Information

  • Product Name
    Bisacodyl
  • Note
    Research use only, not for human use.
  • Brief Description
    Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.
  • Description
    Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.(In Vivo):Bisacodyl (20 mg/kg) results in a decrease in AQP3 protein expression and increased mRNA expression level of TNF-α in the colon of rats . Bisacodyl inhibits water absorption in rat jejunum, ileum, and colon, the degree of inhibition is linearly related to the logarithm of the bisacodyl concentration over the range of 0.05 mg to 2.0 mg per 100 mL . Bisacodyl (10 mg/kg, intragastrically) induces a significant decrease in jejunal NOS activity in rats. Bisacodyl (10 mg/kg, intragastrically) increases the distance traveled by the marker in all time periods . Bisacodyl (5.9 mg/kg) decreases significantly jejunal and colonic (Na + K) ATPase activity as compared to saline-treated rats. Bisacodyl (5.9 mg/kg) increases significantly jejunal and colonic PGE2 content and stimulates jejunal and colonic adenyl cyclase activity as compared to those in control rats without affecting cAMP content . Bisacodyl (4.3 mg/kg) coupled with AOM increases the number of crypt per focus, but not the number of tumors in rats. Bisacodyl (43 mg/kg) significantly increases the number of crypt per focus and tumors in rats .
  • In Vitro
    ——
  • In Vivo
    Bisacodyl (20 mg/kg) results in a decrease in AQP3 protein expression and increased mRNA expression level of TNF-α in the colon of rats . Bisacodyl inhibits water absorption in rat jejunum, ileum, and colon, the degree of inhibition is linearly related to the logarithm of the bisacodyl concentration over the range of 0.05 mg to 2.0 mg per 100 mL . Bisacodyl (10 mg/kg, intragastrically) induces a significant decrease in jejunal NOS activity in rats. Bisacodyl (10 mg/kg, intragastrically) increases the distance traveled by the marker in all time periods . Bisacodyl (5.9 mg/kg) decreases significantly jejunal and colonic (Na + K) ATPase activity as compared to saline-treated rats. Bisacodyl (5.9 mg/kg) increases significantly jejunal and colonic PGE2 content and stimulates jejunal and colonic adenyl cyclase activity as compared to those in control rats without affecting cAMP content . Bisacodyl (4.3 mg/kg) coupled with AOM increases the number of crypt per focus, but not the number of tumors in rats. Bisacodyl (43 mg/kg) significantly increases the number of crypt per focus and tumors in rats .
  • Synonyms
    Bisacodyl, Durolax, Dulcolax, Fenilaxan, Neolax, Ulcolax
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    603-50-9
  • Formula Weight
    361.39
  • Molecular Formula
    C22H19NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 72 mg/mL (199.23 mM)
  • SMILES
    CC(OC1=CC=C(C(C2=CC=C(OC(C)=O)C=C2)C3=NC=CC=C3)C=C1)=O
  • Chemical Name
    (pyridin-2-ylmethylene)bis(4,1-phenylene) diacetate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ikarashi N, et al. Am J Physiol Gastrointest Liver Physiol, 2011, 301(5), G887-895.
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