
Binodenoson
CAS No. 144348-08-3
Binodenoson( MRE-0470 | WRC 0470 | 2-(cyclohexylmethylidenehydrazino)adenos )
Catalog No. M28731 CAS No. 144348-08-3
Binodenoson is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 267 | Get Quote |
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10MG | 402 | Get Quote |
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25MG | 665 | Get Quote |
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50MG | 888 | Get Quote |
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100MG | 1251 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameBinodenoson
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NoteResearch use only, not for human use.
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Brief DescriptionBinodenoson is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging.
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DescriptionBinodenoson is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging.(In Vitro):2-(cyclohexylmethylidenehydrazino)adenos (30-300 nM) decreases oxidative activity of tumor necrosis factor-α–primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram.(In Vivo):2-(cyclohexylmethylidenehydrazino)adenos (infused 0-0.9 μg/kg/h; adult Wistar rat; rat bacterial meningitis model), with or without rolipram (0-0.01 μg/kg/h), inhibits pleocytosis and reduces the lipopolysaccharide-induced increase in blood-brain barrier permeability (BBBP), indicative of decreased neutrophil-induced damage.
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In VitroBinodenoson (MRE-0470) (30-300 nM) decreases oxidative activity of tumor necrosis factor-α–primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram.
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In VivoBinodenoson (infused 0-0.9 μg/kg/h; adult Wistar rat; rat bacterial meningitis model), with or without rolipram (0-0.01 μg/kg/h), inhibits pleocytosis and reduces the lipopolysaccharide-induced increase in blood-brain barrier permeability (BBBP), indicative of decreased neutrophil-induced damage.
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SynonymsMRE-0470 | WRC 0470 | 2-(cyclohexylmethylidenehydrazino)adenos
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PathwayApoptosis
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TargetAdenosine Receptor
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Recptor5-HT1A
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Research Area——
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Indication——
Chemical Information
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CAS Number144348-08-3
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Formula Weight391.432
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Molecular FormulaC17H25N7O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (319.35 mM)
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SMILESNc1nc(NN=CC2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Stephen M. Stahl, et al. Effectiveness of ipsapirone, a 5-HT-1A partial agonist, in major depressive disorder: support for the role of 5-HT-1A receptors in the mechanism of action of serotonergic antidepressants. Int J Neuropsychopharmacol. 1998 Jul;1(1)
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