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Bimolane

CAS No. 74550-97-3

Bimolane( AT-1727 | AT1727 | CCRIS 7574 | Bimolane )

Catalog No. M19065 CAS No. 74550-97-3

Bimolane is a topoisomerase II inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 32 In Stock
5MG 47 In Stock
10MG 78 In Stock
25MG 187 In Stock
50MG 324 In Stock
100MG 443 In Stock
500MG 1008 In Stock
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Biological Information

  • Product Name
    Bimolane
  • Note
    Research use only, not for human use.
  • Brief Description
    Bimolane is a topoisomerase II inhibitor.
  • Description
    Bimolane is a topoisomerase II inhibitor. Bimolane has been widely used in China as an anti-neoplastic agent and for the treatment of psoriasis. Bimolane is also a leukemogenic agent and is thought to exert its effects through the inhibition of topoisomerase II. The results of enzyme and DNA titration assays indicate that inhibition of topoisomerase II by bimolane occurred through interactions with DNA, similar to the mechanism seen with the epipodophyllotoxin-type inhibitors. These results provide evidence that bimolane is an inhibitor of topoisomerase II in vitro.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AT-1727 | AT1727 | CCRIS 7574 | Bimolane
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Topo II
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    74550-97-3
  • Formula Weight
    452.51
  • Molecular Formula
    C20H32N6O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N1(C(=O)CN(CC1=O)CCN1CC(=O)N(C(=O)C1)CN1CCOCC1)CN1CCOCC1
  • Chemical Name
    1-(morpholin-4-ylmethyl)-4-[2-[4-(morpholin-4-ylmethyl)-3,5-dioxopiperazin-1-yl]ethyl]piperazine-2,6-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Vuong MC, Hasegawa LS, Eastmond DA. A comparative study of the cytotoxic and genotoxic effects of ICRF-154 and bimolane, two catalytic inhibitors of topoisomerase II. Mutat Res. 2013 Jan 20;750(1-2):63-71.
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