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Bigelovin

CAS No. 3668-14-2

Bigelovin ( —— )

Catalog No. M24325 CAS No. 3668-14-2

Bigelovin is a selective retinoid X receptor α agonist.?Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a potent cytotoxic sesquiterpene lactone from Inula sp.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Bigelovin
  • Note
    Research use only, not for human use.
  • Brief Description
    Bigelovin is a selective retinoid X receptor α agonist.?Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a potent cytotoxic sesquiterpene lactone from Inula sp.
  • Description
    Bigelovin is a selective retinoid X receptor α agonist.?Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a potent cytotoxic sesquiterpene lactone from Inula sp.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis;Reactive Oxygen Species;retinoid X receptor α
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    3668-14-2
  • Formula Weight
    304.3
  • Molecular Formula
    C17H20O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@H](C[C@@H]([C@H]([C@@H]([C@]12C)OC(C)=O)C3=C)OC3=O)[C@@H]2C=CC1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bei Wang, et al. Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer. Biochem Biophys Res Commun. 2018 May 5;499(2):156-163.
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