Betamethasone

Research use only, not for human use.

Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.

Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.(In Vitro):Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells.Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis.(In Vivo):Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation. Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain.

Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells.Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis.

Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation.Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain. Animal Model:Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges Dosage:0.48 mg Administration:Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h. Result:Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion.The reduction in CBF was diminished to about 25-30 % after 48 h of infusion.

NSC 39470 | SCH 4831

Endocrinology/Hormones

GR

Glucocorticoid Receptor

Inflammation/Immunology

——

378-44-9

392.46

C22H29FO5

>98% (HPLC)

Ethanol: 10 mg/mL (25.48 mM); DMSO: 79 mg/mL (201.29 mM)

O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@](C(CO)=O)(O)[C@@H](C)C[C@@]4([H])[C@]3([H])CCC2=C1

(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one.

(-20℃)

With Ice Pack

≥ 2 years