Benfotiamine ( Benzoylthiamine monophosphate )

Catalog No. M13604 CAS No. 22457-89-2

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Product Name

Benfotiamine
Note

Research use only, not for human use.
Brief Description

Benfotiamine, the lipid-soluble thiamine derivative used as a treatment for diabetic neuropathy.
Description

Benfotiamine, the lipid-soluble thiamine derivative used as a treatment for diabetic neuropathy, can inhibit three major pathways(the hexosamine pathway, the advanced glycation end product (AGE) formation pathway and the diacylglycerol (DAG)protein kinase C (PKC) pathway）of hyperglycemic damage and prevent experimental diabetic retinopathy. Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1) for treating sciatica and other painful nerve conditions. More effective at increasing thiamin levels in blood and tissues than water-soluble salts like the previous vitamin B1.
Synonyms

Benzoylthiamine monophosphate
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Neurological Disease
Indication

——

CAS Number

22457-89-2
Formula Weight

466.46
Molecular Formula

C19H23N4O6PS
Purity

>98%(HPLC)
Solubility

Soluble in DMSO
SMILES

O=C(S/C(CCOP(O)(O)=O)=C(N(CC1=CN=C(C)N=C1N)C=O)/C)C2=CC=CC=C2
Chemical Name

(Z)-S-(2-(N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamido)-5-(phosphonooxy)pent-2-en-3-yl) benzothioate

1.Bozic I, et al. PLoS One. 2015 Feb 19;10(2):e0118372.

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