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Becampanel

CAS No. 188696-80-2

Becampanel( AMP 397 )

Catalog No. M12950 CAS No. 188696-80-2

Becampanel (AMP 397) potent, competitive antagonist of the AMPA receptor (AMPAR) with IC50 of 11 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Becampanel
  • Note
    Research use only, not for human use.
  • Brief Description
    Becampanel (AMP 397) potent, competitive antagonist of the AMPA receptor (AMPAR) with IC50 of 11 nM.
  • Description
    Becampanel (AMP 397) potent, competitive antagonist of the AMPA receptor (AMPAR) with IC50 of 11 nM; has anticonvulsant activity for the treatment of epilepsy, neuropathic pain and cerebral ischemia.Epilepsy Phase 2 Discontinued.
  • In Vitro
    Becampanel is negative in a mouse lymphoma tk assay, which includes a 24 h treatment without S9. A weak micronucleus induction in vitro is found at the highest concentrations tested in V79 cells with S9.
  • In Vivo
    Becampanel is negative in the following in vivo studies, which includes the maximum tolerated doses of 320 mg/kg in mice and 2000 mg/kg in rats. Becampanel has no genotoxic potential in vivo.
  • Synonyms
    AMP 397
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    iGluR
  • Research Area
    Neurological Disease
  • Indication
    Epilepsy

Chemical Information

  • CAS Number
    188696-80-2
  • Formula Weight
    330.191
  • Molecular Formula
    C10H11N4O7P
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C(NC2=C(C(CNCP(O)(O)=O)=CC([N+]([O-])=O)=C2)N1)=O
  • Chemical Name
    ((((7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl)amino)methyl)phosphonic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kwan P, et al. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22. 2. Citraro R, et al. Expert Opin Ther Targets. 2014 Mar;18(3):319-34.
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