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Batefenterol

CAS No. 743461-65-6

Batefenterol( GSK961081 | TD-5959 )

Catalog No. M15839 CAS No. 743461-65-6

A bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Batefenterol
  • Note
    Research use only, not for human use.
  • Brief Description
    A bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.
  • Description
    A bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively; shows weak effect on β1; the first MABA compound to enter clinical trials and demonstrate proof of concept and efficacy in COPD.COPD Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GSK961081 | TD-5959
  • Pathway
    GPCR/G Protein
  • Target
    mAChR
  • Recptor
    hM2|hM3|β2
  • Research Area
    Inflammation/Immunology
  • Indication
    COPD

Chemical Information

  • CAS Number
    743461-65-6
  • Formula Weight
    740.2438
  • Molecular Formula
    C40H42ClN5O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    O=C(OC1CCNCC1)NC2=CC=CC=C2(CCC(NC3=CC(OC)=C(CNC[C@H](O)C4=CC=C(O)C5=C4C=CC(N5)=O)C=C3Cl)=O)C6=CC=CC=C6
  • Chemical Name
    Carbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hughes AD, et al. J Med Chem. 2015 Mar 26;58(6):2609-22. 2. Ambery C, et al. Drugs R D. 2015 Sep;15(3):281-91. 3. Ambery C, et al. Clin Pharmacol Drug Dev. 2016 Sep;5(5):399-407.
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