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BTTAA

CAS No. 1334179-85-9

BTTAA( —— )

Catalog No. M11329 CAS No. 1334179-85-9

A Cu(I)-stabilizing ligand that shows high activity in accelerating the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC); BTTAA-Cu(I) catalyst is the optimal choice for cell surface azide-alkyne ligation, mediates CuAAC and copper-free click chemistry.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BTTAA
  • Note
    Research use only, not for human use.
  • Brief Description
    A Cu(I)-stabilizing ligand that shows high activity in accelerating the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC); BTTAA-Cu(I) catalyst is the optimal choice for cell surface azide-alkyne ligation, mediates CuAAC and copper-free click chemistry.
  • Description
    A Cu(I)-stabilizing ligand that shows high activity in accelerating the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC); BTTAA-Cu(I) catalyst is the optimal choice for cell surface azide-alkyne ligation, mediates CuAAC and copper-free click chemistry.
  • In Vitro
    BTTAAis a Cu(I)-stabilizing ligand. Using the Glu18AzF mutant of ubiquitin as a model system with C3-Tm3+ and C4-Tm3+, Cu-BTTAA performs significantly better as a catalyst than Cu-THPTA or Cu-TBTA. BTTAA proves to perform much better than THPTA (tris[(1-hydroxy-propyl-1H-1,2,3-triazol-4-yl)methyl]amine) or TBTA (tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADCs Linker/Click Chemistry
  • Recptor
    ADCs Linker/Click Chemistry
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    1334179-85-9
  • Formula Weight
    430.5073
  • Molecular Formula
    C19H30N10O2
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: ≥ 34 mg/mL
  • SMILES
    CC(C)(C)N1C=C(N=N1)CN(CC2=CN(N=N2)CC(=O)O)CC3=CN(N=N3)C(C)(C)C
  • Chemical Name
    1H-1,2,3-Triazole-1-acetic acid, 4-[[bis[[1-(1,1-dimethylethyl)-1H-1,2,3-triazol-4-yl]methyl]amino]methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Loh CT, et al. Bioconjug Chem. 2013 Feb 20;24(2):260-8. 2. Besanceney-Webler C, et al. Angew Chem Int Ed Engl. 2011 Aug 22;50(35):8051-6.
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