Cart
sales@molnova.com
BTM-3528
CAS No. 2054998-45-5
BTM-3528( —— )
Catalog No. M37219 CAS No. 2054998-45-5
BTM-3528 is an activator of the mitochondrial protease OMA1 with anticancer activity.BTM-3528 activates the ISR via the mitochondrial protease OMA1, inducing OMA1-dependent cleavage of DELE1 and OPA1 and mitochondrial fragmentation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 737 | Get Quote |
|
| 5MG | 1036 | Get Quote |
|
| 10MG | 1226 | Get Quote |
|
| 25MG | 1536 | Get Quote |
|
| 50MG | 2006 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBTM-3528
-
NoteResearch use only, not for human use.
-
Brief DescriptionBTM-3528 is an activator of the mitochondrial protease OMA1 with anticancer activity.BTM-3528 activates the ISR via the mitochondrial protease OMA1, inducing OMA1-dependent cleavage of DELE1 and OPA1 and mitochondrial fragmentation.
-
DescriptionBTM-3528 is an activator of the mitochondrial protease OMA1 and mediates excessive activation of the mitochondrial integrated stress response (ISR). BTM-3528 stimulates OMA1-dependent DELE1 and OPA1 cleavage and mitochondrial fragmentation. BTM-3528 activates eIF2α kinase HRI, inducing cell growth arrest and apoptosis. BTM-3528 has anticancer activity against multiple DLBCL cell lines and has in vivo inhibitory potency in a mouse model xenografted with human DLBCL SU-DHL-10 cells.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2054998-45-5
-
Formula Weight521.55
-
Molecular FormulaC24H19F4N3O2S2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(O)C1=C(C=2C=CC=C(F)C2)C(=NN1C3=NC(=C(S3)SC(C)C)C=4C=CC(=CC4)C(F)(F)F)C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Schwarzer A, et al. Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1. Mol Cancer Ther. 2023 Aug 30.. .?
molnova catalog
related products
-
(Rac)-Idroxioleic ac...
Minerval is a fatty acid amide hydrolase inhibitor with anti-tumor effect.
-
Aurintricarboxylic a...
Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases.
-
3BDO
3BDO is a new mTOR activator. 3BDO inhibits autophagy.
