BTB-1

Research use only, not for human use.

BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A.

BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18A’s MT-stimulated ATPase activity, with an IC50 of 1.7–1.9 M . It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18A’s MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the nature of Kif18A’s double functionality within mitosis and assessing for potential therapeutic utilities.

BTB1; BTB 1 ; BTB-1

Others

Other Targets

mitotic kinesin Kif18A

Cancer

——

86030-08-2

297.71

C12H8ClNO4S

98%

DMSO : ≥ 100 mg/mL; 335.90 mM

O=S(=O)(c1ccc(Cl)cc1[N+](=O)[O-])c1ccccc1

4-chloro-2-nitro-1-(phenylsulfonyl)benzene

(-20℃)

With Ice Pack

≥ 2 years