BT18( —— )

Catalog No. M24975 CAS No. 924811-53-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

BT18
Note

Research use only, not for human use.
Brief Description

BT18 is a mimic with function similar to glial cell line-derived neurotrophic factor (GDNF).
Description

BT18 is a mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 has an effect on RET receptor tyrosine kinase RetA and GDNF family receptor GFRα1 function.
In Vitro

BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines.BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines.BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 μM both in GFP-transfected and in GFRD1-transfected cells. Western Blot Analysis Cell Line:MG87RET cell lines Concentration:50 μM Incubation Time:1, 5, 15, 45, 90 minutes Result:Activated AKT and ERK1/2 in time-dependently.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

CAS Number

924811-53-0
Formula Weight

637.64
Molecular Formula

C30H31F4N3O6S
Purity

>98% (HPLC)
Solubility

DMSO: 98 mg/mL (153.69 mM; Need ultrasonic)
SMILES

COc(ccc(S(N(CC1)Cc(cc2OC)c1cc2OC)(=O)=O)c1)c1N(CC1)CCN1C(c(cc1)c(C(F)(F)F)cc1F)=O
Chemical Name

——