
BT173
CAS No. 2232180-74-2
BT173( —— )
Catalog No. M28979 CAS No. 2232180-74-2
BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-?1/Smad3 pathway.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 393 | In Stock |
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10MG | 581 | In Stock |
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25MG | 888 | In Stock |
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50MG | 1242 | In Stock |
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100MG | 1674 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameBT173
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NoteResearch use only, not for human use.
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Brief DescriptionBT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-?1/Smad3 pathway.
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DescriptionBT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-?1/Smad3 pathway.(In Vitro):BT173 strongly inhibited the ability of HIPK2 to potentiate the downstream transcriptional activity of Smad3 in kidney tubular cells.?Binding of BT173 to HIPK2 did not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. In vitro, treatment with BT173 inhibited TGF-β1–induced Smad3 phosphorylation and Smad3 target gene expression in human renal tubular epithelial cells. (In Vivo):In vivo, administration of BT173 decreased Smad3 phosphorylation and mitigated renal fibrosis and deposition of extracellular matrix in unilateral ureteral obstruction and Tg26 mouse models of renal fibrosis .
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2232180-74-2
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Formula Weight382.21
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Molecular FormulaC18H12BrN3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1=CC=C2C=C(C3=NC(C4=CC=C(Br)C=C4)=NO3)C=NC2=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cheng X, Ma S. [Pd(PPh3)4]-catalyzed diastereoselective synthesis of trans-1,2-diazetidines from 2,3-allenyl hydrazines and aryl halides. Angew Chem Int Ed Engl. 2008;47(24):4581-3.
molnova catalog



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