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BT-13

CAS No. 924537-98-4

BT-13( —— )

Catalog No. M24974 CAS No. 924537-98-4

BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 349 In Stock
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Biological Information

  • Product Name
    BT-13
  • Note
    Research use only, not for human use.
  • Brief Description
    BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.
  • Description
    BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Rats induced by ligation of left L5 and L6 spinal nerves.Dosage:5-25 mg/kg, dissolved in sesame oil containing 5% DMSO.Administration:Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12.Result:20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.
  • Synonyms
    ——
  • Pathway
    Tyrosine Kinase
  • Target
    c-RET
  • Recptor
    RET
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    924537-98-4
  • Formula Weight
    517.54
  • Molecular Formula
    C23H27F4N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 25 mg/mL (48.31 mM; Need ultrasonic)
  • SMILES
    O=S(C1=CC=C(OC)C(N2CCN(C(C3=CC=C(F)C=C3C(F)(F)F)=O)CC2)=C1)(N(CC)CC)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sidorova YA, et al. A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat. Front Pharmacol. 2017 Jun 21;8:365.
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