BS-181

CAS No. 1092443-52-1

BS-181 ( BS 181;BS181 )

Catalog No. M10348 CAS No. 1092443-52-1

BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 79 In Stock
10MG 135 In Stock
50MG 448 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    BS-181
  • Note
    Research use only, not for human use.
  • Brief Description
    BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM.
  • Description
    BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM, 40-fold selectivity over CDK2/cycE and no significant activity against CDK1/cycB, CDK4/cycD1, CDK5/p35NCK, CDK6/cycD1, and CDK9/cycT (IC50>1 uM); promotes cell cycle arrest and inhibits cancer cell growth in a panel of cell lines representing a range of tumor types (IC50=1.5 to 37 uM), inhibits the phosphorylation of CDK7 substrates, inhibits phosphorylation of the RNA polymerase II COOH-terminal domain (CTD) at P-Ser5 (IC50=9 uM), inhibits RB phosphorylation at Ser795 and Ser821 (IC50=15 uM); induces apoptosis in vitro, and shows antitumor effects in vivo.
  • Synonyms
    BS 181;BS181
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK7
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1092443-52-1
  • Formula Weight
    380.53
  • Molecular Formula
    C22H32N6
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1
  • Chemical Name
    Pyrazolo[1,5-a]pyrimidine-5,7-diamine, N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ali S, et al. Cancer Res. 2009 Aug 1;69(15):6208-15.
2. Kelso TW, et al. Mol Cell Biol. 2014 Oct 1;34(19):3675-88.
3. Wang BY, et al. Drug Des Devel Ther. 2016 Mar 16;10:1181-9.
4. Li B, et al. Cancer Res. 2017 Jul 15;77(14):3834-3845.
molnova catalog
related products
  • RO5454291

    RO5258638 is a small molecule inhibitor of CDK5-p25 protein-protein interaction with IC50 of 1.39 uM.

  • CDK7 and 9 inhibitor...

    A potent, selective transcriptional CDK inhibitor with Ki of 2.3 and 0.38 nM for CDK7 and CDK9, respectively; displays >30-fold selectivity over CDK1/2/4, inhibits VEGFR2 with IC50 of 180 nM in a panel of non-CDK kinases.

  • WHI-P180

    WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.