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BRD6989
CAS No. 642008-81-9
BRD6989( BRD-6989 | BRD 6989 )
Catalog No. M15440 CAS No. 642008-81-9
A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 60 | Get Quote |
|
| 10MG | 88 | Get Quote |
|
| 25MG | 186 | Get Quote |
|
| 50MG | 332 | Get Quote |
|
| 100MG | 494 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBRD6989
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM).
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DescriptionA novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM); inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs, selectively upregulates IL-10 with EC50 of 1 uM.
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In Vitro——
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In Vivo——
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SynonymsBRD-6989 | BRD 6989
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number642008-81-9
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Formula Weight264.332
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Molecular FormulaC16H16N4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (94.58 mM)
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SMILESCC1CCC2=C(C1)C(=C(C(=N2)N)C#N)C3=CN=CC=C3
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Chemical Name2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Johannessen L, et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108.
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