BRD6989 ( BRD-6989;BRD 6989 )

Catalog No. M15440 CAS No. 642008-81-9

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Datasheet

HNMR

HPLC

MSDS

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Product Name

BRD6989
Note

Research use only, not for human use.
Brief Description

A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM).
Description

A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM); inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs, selectively upregulates IL-10 with EC50 of 1 uM.
Synonyms

BRD-6989;BRD 6989
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

Inflammation/Immunology
Indication

——

CAS Number

642008-81-9
Formula Weight

264.33
Molecular Formula

C16H16N4
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1CCC2=C(C1)C(=C(C(=N2)N)C#N)C3=CN=CC=C3
Chemical Name

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

1. Johannessen L, et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108.

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