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BRD5631

CAS No. ——

BRD5631( BRD 5631 | BRD-5631 )

Catalog No. M16938 CAS No. ——

A small-molecule enhancer of autophagy through an mTOR-independent pathway; significantly reduces the number of eGFP-HDQ74-positive cells, and increases the transcript level of p62 in Atg5+/+ MEFs.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BRD5631
  • Note
    Research use only, not for human use.
  • Brief Description
    A small-molecule enhancer of autophagy through an mTOR-independent pathway; significantly reduces the number of eGFP-HDQ74-positive cells, and increases the transcript level of p62 in Atg5+/+ MEFs.
  • Description
    A small-molecule enhancer of autophagy through an mTOR-independent pathway; significantly reduces the number of eGFP-HDQ74-positive cells, and increases the transcript level of p62 in Atg5+/+ MEFs; significantly reduces levels of endogenous p62 and cell death in NPC1 hiPSC-derived neurons; enhances bacterial clearance and suppresses IL-1β Secretion in an autophagy-dependent manner; a valuable tool for studying the role of autophagy in the context of cellular homeostasis and disease.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BRD 5631 | BRD-5631
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    501.627
  • Molecular Formula
    C30H35N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC(C=C1)=CC2=C1OC[C@H](C)NC[C@H](C)[C@H](OC)CN(C)C2=O)C3=CC=C(C4=CC=CC=C4)C=C3
  • Chemical Name
    N-((3S,6S,7S)-7-methoxy-3,6,9-trimethyl-10-oxo-3,4,5,6,7,8,9,10-octahydro-2H-benzo[k][1]oxa[4,9]diazacyclododecin-12-yl)-[1,1'-biphenyl]-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kuo SY, et al. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4281-7.
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