BRD3731

CAS No. 2056262-08-7

BRD3731( BRD-3731 | BRD 3731 )

Catalog No. M13196 CAS No. 2056262-08-7

BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BRD3731
  • Note
    Research use only, not for human use.
  • Brief Description
    BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM).
  • Description
    BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM); displays excellent selectivity in a penal of 311 kinases, displays reduced potency toward the GSK3β mutant (D133E) with IC50 of 53 nM; induces β-catenin stabilization starting at 20 uM in the HL-60 AML cell line, decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation, resulting in increased β-catenin.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BRD-3731 | BRD 3731
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    GSK-3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2056262-08-7
  • Formula Weight
    377.532
  • Molecular Formula
    C24H31N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (529.77 mM)
  • SMILES
    ——
  • Chemical Name
    (R)-4,7,7-trimethyl-3-neopentyl-4-phenyl-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wagner FF, et al. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460.
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