BRD3731

Research use only, not for human use.

BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM).

BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM); displays excellent selectivity in a penal of 311 kinases, displays reduced potency toward the GSK3β mutant (D133E) with IC50 of 53 nM; induces β-catenin stabilization starting at 20 uM in the HL-60 AML cell line, decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation, resulting in increased β-catenin.

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BRD-3731 | BRD 3731

PI3K/Akt/mTOR signaling

GSK-3

GSK-3

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2056262-08-7

377.532

C24H31N3O

>98% (HPLC)

In Vitro:?DMSO : 200 mg/mL (529.77 mM)

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(R)-4,7,7-trimethyl-3-neopentyl-4-phenyl-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one

(-20℃)

With Ice Pack

≥ 2 years