BRD3731( BRD-3731 | BRD 3731 )

Catalog No. M13196 CAS No. 2056262-08-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BRD3731
Note

Research use only, not for human use.
Brief Description

BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM).
Description

BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM); displays excellent selectivity in a penal of 311 kinases, displays reduced potency toward the GSK3β mutant (D133E) with IC50 of 53 nM; induces β-catenin stabilization starting at 20 uM in the HL-60 AML cell line, decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation, resulting in increased β-catenin.
In Vitro

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In Vivo

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Synonyms

BRD-3731 | BRD 3731
Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

GSK-3
Research Area

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Indication

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CAS Number

2056262-08-7
Formula Weight

377.532
Molecular Formula

C24H31N3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 200 mg/mL (529.77 mM)
SMILES

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Chemical Name

(R)-4,7,7-trimethyl-3-neopentyl-4-phenyl-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one

1. Wagner FF, et al. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460.

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