BRD1652( BRD 1652 )

Catalog No. M12286 CAS No. 1597438-92-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

BRD1652
Note

Research use only, not for human use.
Brief Description

BRD1652 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 0.4 nM/4 nM for GSK3α/GSK3β respectively.
Description

BRD1652 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 0.4 nM/4 nM for GSK3α/GSK3β respectively; displays >40 fold selectivity over CDKs, ROS and remarkable selectivity versus the kinome; causes a dramatic decrease in autophosphorylation at Tyr279 (pGSK3α) and Tyr216 (pGSK3β) with longer exposure (24h); attenuates amphetamine-induced hyperactivity (AIH) in mice; exhibits superior pharmacokinetic properties.
In Vitro

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In Vivo

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Synonyms

BRD 1652
Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

GSK-3
Research Area

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Indication

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CAS Number

1597438-92-0
Formula Weight

375.395
Molecular Formula

C20H20F3N3O
Purity

>98% (HPLC)
Solubility

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SMILES

O=C1C2=C(NC3=NNC(C(F)(F)F)=C3[C@]2(C)C4=CC=CC=C4)CC(C)(C)C1
Chemical Name

(S)-4,7,7-Trimethyl-4-phenyl-3-trifluoromethyl-2,4,6,7,8,9-hexahydro-pyrazolo[3,4-b]quinolin-5-one

1. Wagner FF, et al. ACS Chem Biol. 2016 Jul 15;11(7):1952-63.

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