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BRCA1-IN-2
CAS No. 1622262-55-8
BRCA1-IN-2( —— )
Catalog No. M32817 CAS No. 1622262-55-8
BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 454 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBRCA1-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionBRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.
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DescriptionBRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1622262-55-8
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Formula Weight544.54
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Molecular FormulaC26H33N4O7P
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (183.64 mM; Ultrasonic )
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SMILESC(CC(N[C@H](C(NCC(NCCCCC1=CC=CC=C1)=O)=O)COP(=O)(O)O)=O)C=2C=3C(NC2)=CC=CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Na Z, et al. Protein-Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays. Methods Mol Biol. 2017;1518:139-156.?
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