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BR111

CAS No. 1037092-93-5

BR111( BR 111 )

Catalog No. M10184 CAS No. 1037092-93-5

BR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85?±?40 ?nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BR111
  • Note
    Research use only, not for human use.
  • Brief Description
    BR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85?±?40 ?nM.
  • Description
    BR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85?±?40 ?nM (inhibition of hC3a induced Ca2+ release on human macrophages); displays high selectivity for C3aR over C5aR; inhibits mast cell degranulation, thereby blocking recruitment and activation of macrophages and neutrophils, expression of inflammatory mediators and inflammation in a rat paw edema model.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BR 111
  • Pathway
    Immunology/Inflammation
  • Target
    Complement System
  • Recptor
    Complement System
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1037092-93-5
  • Formula Weight
    450.557
  • Molecular Formula
    C24H26N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (5-benzhydrylthiophene-2-carbonyl)-L-arginine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lohman RJ, et al. Nat Commun. 2017 Aug 24;8(1):351.
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