BQCA

Research use only, not for human use.

BQCA a highly selective allosteric modulator of the M1 mAChR.

BQCA is a potent muscarinic M1 receptor positive allosteric modulator with selectivity for M1 over M2-M5. Stimulation of the cortical muscarinic M1 receptor (CHRM1) is proposed as a treatment for schizophrenia, a hypothesis testable using CHRM1 allosteric modulators. BQCA binds allosterically to M1 to enhance the binding and efficacy of ACh at the receptor. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s.

BQCA, CAS#338747-41-4

Metabolic Enzyme/Protease

Transferase

M1 mAChR

Neurological Disease

——

338747-41-4

309.32

C18H15NO4

98%

DMSO : 5.45 mg/mL. 17.62 mM;

COC1=CC=C(C=C1)CN2C=C(C(=O)C3=CC=CC=C32)C(=O)O

1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years