BPTU ( BPTU; BMS-646786; BMS 646786 )

Catalog No. M17632 CAS No. 870544-59-5

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Product Name

BPTU
Note

Research use only, not for human use.
Brief Description

Allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle.
Description

Allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contraction of rat and mouse colon induced by electrical field stimulation, nicotine and P2Y agonists. Antithrombotic; reduces platelet aggregation.
Synonyms

BPTU; BMS-646786; BMS 646786
Pathway

Others
Target

Other Targets
Recptor

P2Y1
Research Area

Cardiovascular Disease
Indication

——

CAS Number

870544-59-5
Formula Weight

445.42
Molecular Formula

C23H22F3N3O3
Purity

98%
Solubility

DMSO : ≥ 33.3 mg/mL. 74.76 mM; H2O : < 0.1 mg/mL
SMILES

CC(C)(C)C1=CC=CC=C1OC2=C(C=CC=N2)NC(=O)NC3=CC=C(C=C3)OC(F)(F)F
Chemical Name

1-[2-(2-tert-Butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea

1.Abrahamsen B, et al. J Neurosci. 2013 Jan 16;33(3):1068-87.

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