BPH-1358 ( NSC50460 )

Catalog No. M24517 CAS No. 5352-53-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BPH-1358
Note

Research use only, not for human use.
Brief Description

BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor.
Description

BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. aureus in vitro (MIC ~250 ng/mL).
Synonyms

NSC50460
Pathway

Others
Target

Other Targets
Recptor

human bisphosphonate farnesyl diphosphate synthase
Research Area

——
Indication

——

CAS Number

5352-53-4
Formula Weight

601.5
Molecular Formula

C32H30Cl2N6O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC=C(C2=CC=C(C(NC3=CC=CC(C4=NCCN4)=C3)=O)C=C2)C=C1)NC5=CC=CC(C6=NCCN6)=C5.[H]Cl.[H]Cl
Chemical Name

——

1.Zhu W, et al. Antibacterial drug leads: DNA and enzyme multitargeting. J Med Chem. 2015 Feb 12;58(3):1215-27.

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