BP-897( BP897 )

Catalog No. M14019 CAS No. 314776-92-6

BP-897 is the first, potent, selective partial dopamine D3 receptor agonist with Ki of 0.92 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	178	Get Quote
5MG	282	Get Quote
10MG	439	Get Quote
25MG	707	Get Quote
50MG	1008	Get Quote
100MG	1332	Get Quote
500MG	2655	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

BP-897
Note

Research use only, not for human use.
Brief Description

BP-897 is the first, potent, selective partial dopamine D3 receptor agonist with Ki of 0.92 nM.
Description

BP-897 is the first, potent, selective partial dopamine D3 receptor agonist with Ki of 0.92 nM; displays 70 times lower affinity for D2 (Ki=61 nM), low affinities for D1 and D4 (Ki= 3 and 0.3 uM) and α1 and α2 adrenergic receptor (Ki=60 and 83 nM), negligible affinities (Ki>1 uM) for muscarinic, histamine and opiate receptors; inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects.Parkinson Disease Phase 2 Discontinued.
In Vitro

——
In Vivo

Animal Model:Male Listar hooded rats Dosage:0.05, 0.5, 1 mg/kg Administration:i.p.; 30 min before the session Result:Reduced cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression.
Synonyms

BP897
Pathway

GPCR/G Protein
Target

Dopamine Receptor
Recptor

Dopamine Receptor
Research Area

Neurological Disease
Indication

Parkinson Disease

Chemical Information

CAS Number

314776-92-6
Formula Weight

417.553
Molecular Formula

C26H31N3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (275.33 mM)
SMILES

O=C(NCCCCN1CCN(C2=CC=CC=C2OC)CC1)C3=CC=C4C=CC=CC4=C3
Chemical Name

N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Pilla M, et al. Nature. 1999 Jul 22;400(6742):371-5. 2. Wood MD, et al. Eur J Pharmacol. 2000 Oct 27;407(1-2):47-51. 3. Wicke K, et al. Eur J Pharmacol. 2001 Jul 20;424(2):85-90.

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