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BOC-D-FMK

CAS No. 634911-80-1

BOC-D-FMK( Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester )

Catalog No. M15400 CAS No. 634911-80-1

BOC-D-FMK is a cell-permeable, irreversible, broad spectrum caspase inhibitor, inhibits apoptosis stimulated by TNF-α with IC50 of 39 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BOC-D-FMK
  • Note
    Research use only, not for human use.
  • Brief Description
    BOC-D-FMK is a cell-permeable, irreversible, broad spectrum caspase inhibitor, inhibits apoptosis stimulated by TNF-α with IC50 of 39 uM.
  • Description
    BOC-D-FMK is a cell-permeable, irreversible, broad spectrum caspase inhibitor, inhibits apoptosis stimulated by TNF-α with IC50 of 39 uM; inhibits TNFα-stimulated reactive oxygen species (ROS) generation, prevents genistein-induced apoptosis of p815 cells at 50 uM; shows neuroprotective effects on spinal motoneurons (MNs) after root avulsion in neonatal rats, suppresses polyethylene particle-induced osteolysis in mice.
  • In Vitro
    Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39 μM. BocD-fmk at 50 μM prevents genistein-induced apoptosis of p815 cells. Confocal microscopy shows that the release of mitochondrial apoptotic factors is inhibited by BocD-fmk.
  • In Vivo
    Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle.
  • Synonyms
    Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Caspase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    634911-80-1
  • Formula Weight
    263.2627
  • Molecular Formula
    C11H18FNO5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 125 mg/mL
  • SMILES
    CC(C)(C)OC(=O)NC(CC(=O)OC)C(=O)CF
  • Chemical Name
    Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cowburn AS, et al. Blood. 2005 Apr 1;105(7):2970-2. 2. Yee SB, et al. Exp Mol Med. 2006 Dec 31;38(6):634-42. 3. Chan YM, et al. Exp Neurol. 2003 Jun;181(2):190-203. 4. Landgraeber S, et al. Apoptosis. 2009 Feb;14(2):173-81.
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