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BMT-124110

CAS No. 1679371-59-5

BMT-124110( —— )

Catalog No. M32813 CAS No. 1679371-59-5

BMT-124110 is a selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibited BMP-2 induced protein kinase BIKE with IC50 of 17 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BMT-124110
  • Note
    Research use only, not for human use.
  • Brief Description
    BMT-124110 is a selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibited BMP-2 induced protein kinase BIKE with IC50 of 17 nM.
  • Description
    BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively.
  • In Vitro
    BMT-124110 shows a cellular IC50 of 3.2±1.4 nM for AAK1.
  • In Vivo
    BMT-124110 is added directly onto the spinal corevd by microiontophoresis, leading to reduction in windup-induced activity in 10 of 14 animals.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    AAK1 (AP2 associated kinase 1)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1679371-59-5
  • Formula Weight
    369.46
  • Molecular Formula
    C21H27N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(C(C)=O)C=1C=C2C=3C(=CC(OC[C@@](CC(C)C)(C)N)=CC3)OCC2=CN1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.?
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