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BMS986187

CAS No. 684238-37-7

BMS986187( —— )

Catalog No. M24699 CAS No. 684238-37-7

BMS986187 is a novel Potent and Selective Positive Allosteric Modulators of the delta-Opioid Receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 215 In Stock
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100MG 484 In Stock
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Biological Information

  • Product Name
    BMS986187
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS986187 is a novel Potent and Selective Positive Allosteric Modulators of the delta-Opioid Receptor.
  • Description
    BMS986187 is a novel Potent and Selective Positive Allosteric Modulators of the delta-Opioid Receptor.
  • In Vitro
    BMS-986187?(1 nM-100 uM) produces little or no activity in agonist mode, but in PAM mode (in the presence of an EC20?of leu-enkephalin (in CHO-OPRD1 cells) or endomorphin 1 (in CHO-OPRM1 cells)) produces a response with an EC50?of 48 nM in CHO-OPRD1 cells and 2?μM in CHO-OPRM1 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    δ-opioid receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    684238-37-7
  • Formula Weight
    470.6
  • Molecular Formula
    C31H34O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    CC1=CC=CC=C1COC2=CC=C(C=C2)C3C4=C(CC(CC4=O)(C)C)OC5=C3C(=O)CC(C5)(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Livingston K E , Stanczyk M A , Burford N , et al. Pharmacological Evidence for a Putative Conserved Allosteric Site on Opioid Receptors[J]. Molecular Pharmacology, 2017:mol.117.109561.
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